What Is Carpal Tunnel Syndrome Carpal tunnel syndrome happens when the median nerve is compressed or pinched in the carpal tunnel. The median nerve and 9 tendons run through the narrow, rigid carpal tunnel at the base of the wrist.The median nerve runs from the forearm to the hand and provides sensation to the palm side of the thumb, the first and second fingers and part of the ring finger (but not the little finger.)Swelling or thickening of the lining of irritated tendons narro [...]