Elevar Therapeutics: Elevar Therapeutics Presents Results from Post-Hoc Analysis of CARES-310 Study Evaluating the Impact of Viral and Non-Viral Etiology on Survival in Hepatocellular Carcinoma

Post-hoc analysis on survival outcomes for camrelizumab plus rivoceranib in patients with viral and non-viral hepatocellular carcinoma (HCC) demonstrated clinically meaningful overall survival and progression-free survival benefit for patients with hepatitis B or C viral infection HCC or non-viral HCCResults presented at ASCO GI January 24 showing favorable survival benefit of using camrelizumab plus rivoceranib as first-line treatment for patients with unresectable HCC, independent of etiologyFORT LEE, N.J., Jan. 24, 2025 (GLOBE NEWSWIRE) -- Elevar Therapeutics, Inc., a portfolio company of HLB Co., Ltd., today announced the results from a post-hoc analysis of the international CARES-310 study evaluating camrelizumab plus rivoceranib vs. sorafenib as a first-line treatment for patients with unresectable hepatocellular carcinoma (uHCC) of viral and non-viral etiology. The post-hoc analysis will be presented in a poster at the 2025 American Society of Clinical Oncology's annual Gastrointestinal Cancers Symposium (ASCO GI) on January 24."This post-hoc analysis of uHCC patients treated with camrelizumab and rivoceranib demonstrated consistent survival benefits across subgroups with hepatitis B, hepatitis C and non-viral etiologies. The exploratory analysis revealed clinically meaningful improvements in both overall survival and progression-free survival, agnostic of the underlying etiology. Importantly, the safety profile of the combination therapy remained manageable and comparable across all subgroups," commented Chris Galloway, M.D., senior vice president of clinical development and medical affairs at Elevar.Results: Median overall survival (mOS) was longer with camrelizumab plus rivoceranib compared with sorafenib in patients with non-viral (HR 0.68 [95% CI 0.39, 1.19]), HCV (HR 0.37 [95% CI 0.162, 0.84]), and HBV etiologies (HR 0.70 [95% CI 0.55, 0.89]). Similarly, median progression free survival (mPFS) was longer with camrelizumab plus rivoceranib compared with sorafenib in patients with non-viral (HR 0.55 [95% CI 0.34, 0.91]), HCV (HR 0.50 [95% CI 0.23, 1.06]), and HBV etiologies (HR 0.57 [95% CI 0.45, 0.72])i.The analysis concluded camrelizumab plus rivoceranib in CARES-310 suggested clinically meaningful mOS benefit in non-viral and viral HCC vs sorafenib and provides assurance of clinical benefit for first line treatment to patients with uHCC independent of etiology.ii2025 ASCO GI Poster Session InformationPoster Session B, Cancers of the Pancreas, Small Bowel and Hepatobiliary Tract: Clinical outcomes of camrelizumab + rivoceranib vs sorafenib (CARES-310) as first-line treatment for patients with unresectable hepatocellular carcinoma (uHCC) of non-viral and viral etiology.Abstract: 578Poster Bd#: C4Presenter: Rachna T. Shroff, MD, FASCOAbout CARES-310The CARES-310 study, an international, randomized, open-label, Phase 3 trial, with 543 patients with uHCC who had not previously received systemic treatment was the first to demonstrate significant progression-free survival (PFS) and overall survival (OS) benefits with ...Full story available on Benzinga.com