LC Sciences Blog Extracellular vesicle contents found in synovial fluid may serve as a diagnostic for arthritic disease

Senescent cells (SnCs) are increasingly recognized as central effector cells in age-related pathologies. Extracellular vesicles (EVs) are potential cellular communication tools through which SnCs exert central effector functions in the local tissue environment. To test this hypothesis in a medical indication that could be validated clinically, researchers from the Buck Institute for Aging and Johns Hopkins University evaluated EV production from SnCs enriched from chondrocytes isolated from human arthritic cartilage.