LC Sciences Blog Targeted NGS is a reliable method for investigating the mitochondrial genome and heteroplasmy
Disrupted mitochondrial functions and genetic variants of mitochondrial DNA (mtDNA) have been observed in different human neoplasms. Next-generation sequencing (NGS) can be used to detect even low heteroplasmy-level mtDNA variants. Researchers from Semmelweis University aimed to investigate the mitochondrial genome in pituitary adenomas by NGS.
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