The growing discussion about the correct use of midline catheters brings up another related issue. What is the definition for vesicant and irritant? What are the differences and similarities?The following definitions are taken from the glossary of the 2011 Infusion Nursing Standards of Practice.Vesicant. An agent capable of causing blistering, tissue sloughing, or necrosis when it escapes from the intended vascular pathway into surrounding tissue.Irritant. An agent capable of producing discomfor [...]