Bruker: Bruker Corporation Unveils New Proteomics Software and Applications for Enhanced Biological Insights at US HUPO

At the 21st Annual US HUPO Conference, Bruker Corporation announced significant advances in 4D-Proteomics performance, software and applications for deeper biological insights. The new AIP enables highly efficient ion transfer from the collision cell to the orthogonal acceleration region of the TOF analyzer of the timsTOF Ultra 2 mass spectrometer. For SCP-relevant amounts of 250 pg, AIP typically generates >15% increases in protein IDs and >20% increases in peptide IDs - to ensure high sequence coverage. Similar improvements are observed in immunopeptidomics. Bruker expects to launch the new AIP on the timsTOF Ultra2 system at ASMS 2025 with timsTOF Ultra 2 field upgradability. DeutEx is software developed by Petr Novak from the Czech Academy of Sciences to analyse hydrogen-deuterium exchange mass spectrometry (HDX-MS). DeutEx is now integrated into the Bruker proteomics ecosystem to support timsTOF, MRMS and MALDI-TOF systems. The new OmniScape 2025b version brings a 10x increase in de novo sequencing performance, detection of truncated variants, and comprehensive overviews of reliable sequence annotation. It also enables the integration of sequence maps derived from different MSn levels (MS2 & MS3), now also including MALDI T³-sequencing. ProteoScape? V.2025c provides updates of Spectronaut and GlycoScape? software. Spectronaut v.19.6 comes with further performance improvements, improved quantity imputation and PTM stoichiometry calculations. GlycoScape v.2025c now offers custom modifications, including choice of glycan building blocks and labeled glycans. Together with a glycoproteomics workflow using the Agilent AssayMAP Bravo, this enables automated, high-throughput glyco-insights, and increases the number of glycopeptides identified by 6x-10x, enabling comprehensive glycoform profiling at scale on timsTOF systems with on-the-fly GlycoScape processing. TwinScape, a unique cloud-based AI-enabled software is now quality monitoring hundreds of customer systems, including nanoElute LCs and the entire timsTOF series. At the 21st Annual US HUPO Conference, Bruker Corporation announced significant advances in 4D-Proteomics performance, software and applications for deeper biological insights. The new AIP enables highly efficient ion transfer from the collision cell to the orthogonal acceleration region of the TOF analyzer of the timsTOF Ultra 2 mass spectrometer. For SCP-relevant amounts of 250 pg, AIP typically generates >15% increases in protein IDs and >20% increases in peptide IDs - to ensure high sequence coverage. Similar improvements are observed in immunopeptidomics. Bruker expects to launch the new AIP on the timsTOF Ultra2 system at ASMS 2025 with timsTOF Ultra 2 field upgradability. DeutEx is software developed by Petr Novak from the Czech Academy of Sciences to analyse hydrogen-deuterium exchange mass spectrometry (HDX-MS). DeutEx is now integrated into the Bruker proteomics ecosystem to support timsTOF, MRMS and MALDI-TOF systems. The new OmniScape 2025b version brings a 10x increase in de novo sequencing performance, detection of truncated variants, and comprehensive overviews of reliable sequence annotation. It also enables the integration of sequence maps derived from different MSn levels (MS2 & MS3), now also including MALDI T³-sequencing. ProteoScape? V.2025c provides updates of Spectronaut and GlycoScape? software. Spectronaut v.19.6 comes with further performance improvements, improved quantity imputation and PTM stoichiometry calculations. GlycoScape v.2025c now offers custom modifications, including choice of glycan building blocks and labeled glycans. Together with a glycoproteomics workflow using the Agilent AssayMAP Bravo, this enables automated, high-throughput glyco-insights, and increases the number of glycopeptides identified by 6x-10x, enabling comprehensive glycoform profiling at scale on timsTOF systems with on-the-fly GlycoScape processing. TwinScape, a unique cloud-based AI-enabled software is now quality monitoring hundreds of customer systems, including nanoElute LCs and the entire timsTOF series.