Repligen: Repligen Launches the CTech SoloVPE PLUS System

Repligen Corporation announced the commercial launch of its CTech SoloVPE PLUS System, the most advanced UV-based Variable Pathlength Technology system now available to biopharmaceutical manufacturers. The SoloVPE PLUS System is engineered to offer unparalleled accuracy, speed, and ease-of-use for at-line ultraviolet-visible (UV-Vis) concentration measurement in complex biological production workflows, from process development scale through cGMP manufacturing. As the bioprocess industry shifts toward higher drug concentration formulations to improve efficiency and reduce production costs, there has been a growing need for faster, more reliable and more accurate analytical tools. The SoloVPE PLUS system addresses this need, utilizing variable pathlength spectroscopy to deliver precise concentration measurements in under 30 seconds, without the need for dilution or background correction. This innovative technology is a significant addition to Repligen's process analytics portfolio, advancing the company's at-line capabilities and complementing both its in-line, real-time FlowVPX®System and fully integrated RPM (Real-time Process Management) TFF Systems. Applications for the SoloVPE PLUS System include measurement of protein concentration (such as for antibody-based drugs, including ADC drug-to-antibody ratio), quantitation of nucleic acids (DNA/RNA) and measurement of mRNA in mRNA-based therapeutics. The SoloVPE Plus System offers several key advantages over current UV-Vis spectroscopy offerings in the market: Streamlined Workflow. reduces process steps by 70%, from a seven-step process to just two - measure and report. Accelerated Acquisition Speed. Doubles the speed of data collection, delivering results in half the time compared to the legacy SoloVPE System. Enhanced Sensitivity and Reproducibility. Measures the widest range of concentrations without dilution--mAbs from 0.01 mg/mL to 320 mg/mL, with an R2 0.999. Minimized Error-Prone Steps. Direct measurement of samples eliminates the need for dilution or additional sample preparation. Optimized Data Management. The CTech ViPER ANLYTX Software integrates SQL for data storage and retrieval, and OPC-UA for standardized communication, enabling a streamlined, agile, and connected system that supports real-time access and scalable bioprocessing operations. Repligen Corporation announced the commercial launch of its CTech SoloVPE PLUS System, the most advanced UV-based Variable Pathlength Technology system now available to biopharmaceutical manufacturers. The SoloVPE PLUS System is engineered to offer unparalleled accuracy, speed, and ease-of-use for at-line ultraviolet-visible (UV-Vis) concentration measurement in complex biological production workflows, from process development scale through cGMP manufacturing. As the bioprocess industry shifts toward higher drug concentration formulations to improve efficiency and reduce production costs, there has been a growing need for faster, more reliable and more accurate analytical tools. The SoloVPE PLUS system addresses this need, utilizing variable pathlength spectroscopy to deliver precise concentration measurements in under 30 seconds, without the need for dilution or background correction. This innovative technology is a significant addition to Repligen's process analytics portfolio, advancing the company's at-line capabilities and complementing both its in-line, real-time FlowVPX®System and fully integrated RPM (Real-time Process Management) TFF Systems. Applications for the SoloVPE PLUS System include measurement of protein concentration (such as for antibody-based drugs, including ADC drug-to-antibody ratio), quantitation of nucleic acids (DNA/RNA) and measurement of mRNA in mRNA-based therapeutics. The SoloVPE Plus System offers several key advantages over current UV-Vis spectroscopy offerings in the market: Streamlined Workflow. reduces process steps by 70%, from a seven-step process to just two - measure and report. Accelerated Acquisition Speed. Doubles the speed of data collection, delivering results in half the time compared to the legacy SoloVPE System. Enhanced Sensitivity and Reproducibility. Measures the widest range of concentrations without dilution--mAbs from 0.01 mg/mL to 320 mg/mL, with an R2 0.999. Minimized Error-Prone Steps. Direct measurement of samples eliminates the need for dilution or additional sample preparation. Optimized Data Management. The CTech ViPER ANLYTX Software integrates SQL for data storage and retrieval, and OPC-UA for standardized communication, enabling a streamlined, agile, and connected system that supports real-time access and scalable bioprocessing operations.