Anatomy Origin: Posterior part of the lateral surface of the zygomatic bone. Insertion: Angle of mouth where its fibres blend with those of levator anguli oris, depressor anguli oris and orbicularis oris. Key Relations: Arises posterior to orbicularis oculi and runs downwards and blends with orbicularis oris before inserting on the angle of the mouth.The post Zygomaticus major appeared first on Pocket Anatomy.